Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous
presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU …

Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies,
variable pathogenesis and diverse outcomes. However, these heterogeneities are not …

Given that the leading clinical conditions associated with acute kidney injury (AKI), namely,
sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is …

Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

An understanding of the pathologic mechanisms of sepsis-induced AKI emphasizes the
important role of maladaptive responses to the septic insult. Preventive and therapeutic …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

AKI is a common clinical condition associated with the risk of develo** CKD and ESKD.
Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly …

Background β-Lactams are routinely used as empirical therapy in critical illness, with
extended concentrations above the minimum inhibitory concentration (MIC) of the infecting …

In patients with acute kidney injury (AKI), optimization of systemic haemodynamics is central
to the clinical management. However, considerable debate exists regarding the efficacy …