Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
[HTML][HTML] Carbon nanotube field-effect transistor (CNT-FET)-based biosensor for rapid detection of SARS-CoV-2 (COVID-19) surface spike protein S1
The large-scale diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is important for traceability and treatment during pandemic outbreaks. We developed a …
2) is important for traceability and treatment during pandemic outbreaks. We developed a …
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Understanding the pathogenesis of occupational coal and silica dust-associated lung disease
Workers in the mining and construction industries are at increased risk of respiratory and
other diseases as a result of being exposed to harmful levels of airborne particulate matter …
other diseases as a result of being exposed to harmful levels of airborne particulate matter …
Recent advances in lung-on-a-chip models
Highlights•Transition from conventional 2D models to 3D and advanced lung-on-a-chip
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
[PDF][PDF] The B1. 351 and P. 1 variants extend SARS-CoV-2 host range to mice
X Montagutelli, M Prot, L Levillayer, EB Salazar… - BioRxiv, 2021 - biorxiv.org
Receptor recognition is a major determinant of viral host range, as well as infectivity and
pathogenesis. Emergences have been associated with serendipitous events of adaptation …
pathogenesis. Emergences have been associated with serendipitous events of adaptation …
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin
The devastating impact of the COVID-19 pandemic caused by SARS–coronavirus 2 (SARS-
CoV-2) has raised important questions about its origins and the mechanism of its transfer to …
CoV-2) has raised important questions about its origins and the mechanism of its transfer to …