The role of the cochlea is to transduce complex sound waves into electrical neural activity in
the auditory nerve. Hair cells of the organ of Corti are the sensory cells of hearing. The inner …

In mammals, the initial bridge between the physical world of sound and perception of that
sound is established by neurons of the spiral ganglion. The cell bodies of these neurons …

This investigation examined the consequences of neonatal deafness and chronic
intracochlear electrical stimulation delivered by a cochlear implant during maturation. Kittens …

A profound sensorineural hearing loss induces significant pathological and atrophic
changes within the cochlea and central auditory pathway. We describe these deafness …

In vitro, cyclic AMP (cAMP) elevation alters neuronal responsiveness to diffusible growth
factors and myelin-associated inhibitory molecules. Here we used an established in vivo …

Cochlear implants can directly activate the auditory system's primary sensory neurons, the
spiral ganglion neurons (SGNs), via circumvention of defective cochlear hair cells. This …

Spiral ganglion neurons (SGNs) are postsynaptic to hair cells and project to the brainstem.
The inner hair cell (IHC) to SGN synapse is susceptible to glutamate excitotoxicity and to …

Low-intensity pulsed ultrasound (LIPUS) stimulation has been shown to increase the
expression of brain-derived neurotrophic factor (BDNF) in astrocytes of an in vitro model and …

The development and maintenance of spiral ganglion neurons (SGNs) appears to be
supported by both neural activity and neurotrophins. Removal of this support leads to their …

We have shown previously that intraocular elevation of cAMP using the cAMP analog 8-(4-
chlorophenylthio)-cAMP (CPT-cAMP) failed to promote axonal regeneration of axotomized …