The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

The bZIP transcription factor Nrf2 controls a genetic program that protects cells from
oxidative damage and maintains cellular redox homeostasis. Keap1, a BTB-Kelch protein, is …

Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of
cellular processes including proliferation, apoptosis, differentiation, survival, cell migration …

Abstract Jun: Fos and Jun: ATF complexes represent two classes of AP-1 dimers that (1)
preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are …

Keap1 is a BTB-Kelch protein that functions as a substrate adaptor protein for a Cul3-
dependent E3 ubiquitin ligase complex. Keap1 targets its substrate, the Nrf2 transcription …

Metastasis, the aggressive spread of a malignant tumor to distant organs, is a major cause of
death in cancer patients. Despite this critical role in cancer outcomes, the molecular …

Nemaline myopathy (NM) is a rare congenital muscle disorder primarily affecting skeletal
muscles that results in neonatal death in severe cases as a result of associated respiratory …

Our understanding of genes that cause skeletal muscle disease has increased
tremendously over the past three decades. Advances in approaches to genetics and …

Background The kelch motif is an ancient and evolutionarily-widespread sequence motif of
44–56 amino acids in length. It occurs as five to seven repeats that form a β-propeller tertiary …