Single-cell sequencing-based technologies will revolutionize whole-organism science
The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …
new genomics, epigenomics, transcriptomics and proteomics technologies. These …
The clockwork embryo: mechanisms regulating developmental rate
M Diaz-Cuadros, O Pourquié - Annual Review of Genetics, 2023 - annualreviews.org
Organismal development requires the reproducible unfolding of an ordered sequence of
discrete steps (cell fate determination, migration, tissue folding, etc.) in both time and space …
discrete steps (cell fate determination, migration, tissue folding, etc.) in both time and space …
Deep learning in label-free cell classification
Label-free cell analysis is essential to personalized genomics, cancer diagnostics, and drug
development as it avoids adverse effects of staining reagents on cellular viability and cell …
development as it avoids adverse effects of staining reagents on cellular viability and cell …
Metabolic regulation of species-specific developmental rates
Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …
despite a broad conservation of the overall sequence of developmental events. Differences …
Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms
O Padovan-Merhar, GP Nair, AG Biaesch, A Mayer… - Molecular cell, 2015 - cell.com
Individual mammalian cells exhibit large variability in cellular volume, even with the same
absolute DNA content, and so must compensate for differences in DNA concentration in …
absolute DNA content, and so must compensate for differences in DNA concentration in …
Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome
AE Teschendorff, T Enver - Nature communications, 2017 - nature.com
The ability to quantify differentiation potential of single cells is a task of critical importance.
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …
overlooked. We have shown that NP cells contain networked mitochondria and that …
Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Fractional killing is the main cause of tumour resistance to chemotherapy. This phenomenon
is observed even in genetically identical cancer cells in homogeneous microenvironments …
is observed even in genetically identical cancer cells in homogeneous microenvironments …
Mitochondrial heterogeneity
Cell-to-cell heterogeneity drives a range of (patho) physiologically important phenomena,
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …
Mitochondrial function and cell size: an allometric relationship
Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption
with increasing organismal size. This is considered a universal law in biology. Here, we …
with increasing organismal size. This is considered a universal law in biology. Here, we …