Pathophysiology of trauma-induced coagulopathy
There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …
Pathophysiological response to trauma-induced coagulopathy: a comprehensive review
Hypercoagulability can occur after severe tissue injury, that is likely related to tissue factor
exposure and impaired endothelial release of tissue plasminogen activator (tPA). In contrast …
exposure and impaired endothelial release of tissue plasminogen activator (tPA). In contrast …
Prehospital plasma in injured patients is associated with survival principally in blunt injury: results from two randomized prehospital plasma trials
Methods We performed a secondary analysis using a harmonized data set derived from two
recent prehospital plasma randomized trials. Identical inclusion/exclusion criteria and …
recent prehospital plasma randomized trials. Identical inclusion/exclusion criteria and …
[HTML][HTML] Resuscitating the endothelial glycocalyx in trauma and hemorrhagic shock
T Anand, AA Reyes, MC Sjoquist, L Magnotti… - Annals of Surgery …, 2023 - journals.lww.com
The endothelium is lined by a protective mesh of proteins and carbohydrates called the
endothelial glycocalyx (EG). This layer creates a negatively charged gel-like barrier between …
endothelial glycocalyx (EG). This layer creates a negatively charged gel-like barrier between …
Traumatized triad of complementopathy, endotheliopathy, and coagulopathy˗ Impact on clinical outcomes in severe polytrauma patients
Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key
pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) …
pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) …
Prehospital point of care testing for the early detection of shock and prediction of lifesaving interventions
SM Galvagno Jr, RA Sikorski, DJ Floccare, P Rock… - Shock, 2020 - journals.lww.com
Methods: Adult trauma patients flown by a helicopter emergency medical service were
prospectively enrolled. Using an i-STAT portable analyzer, data from 16 laboratory tests …
prospectively enrolled. Using an i-STAT portable analyzer, data from 16 laboratory tests …
Exploratory investigation of the plasma proteome associated with the endotheliopathy of trauma
Background: The endotheliopathy of trauma (EoT) is associated with increased mortality
following injury. Herein, we describe the plasma proteome related to EoT in order to provide …
following injury. Herein, we describe the plasma proteome related to EoT in order to provide …
Prehospital plasma transfusion: What does the literature show?
BP Jackson, JL Sperry, MH Yazer - Transfusion Medicine and …, 2021 - karger.com
Background: Early initiation of blood products transfusion after injury has been associated
with improved patient outcomes following traumatic injury. The ability to transfuse patients' …
with improved patient outcomes following traumatic injury. The ability to transfuse patients' …
[HTML][HTML] Pathophysiology of trauma-induced coagulopathy
Trauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop
early after a major injury. There is no universally accepted definition of TIC. However, TIC …
early after a major injury. There is no universally accepted definition of TIC. However, TIC …
The protective role of estrogen on endothelial and glycocalyx barriers after shock conditions: a microfluidic study
LN Diebel, M Wheaton, DM Liberati - Surgery, 2021 - Elsevier
Background Sexual dimorphism has been demonstrated after major trauma and
hemorrhage shock with protective effects related to female sex or estrogen. Traumatic …
hemorrhage shock with protective effects related to female sex or estrogen. Traumatic …