Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Background High-throughput profiling of DNA methylation status of CpG islands is crucial to
understand the epigenetic regulation of genes. The microarray-based Infinium methylation …

The functional complexity of the human transcriptome is not yet fully elucidated. We report a
high-throughput sequence of the human transcriptome from a human embryonic kidney and …

Forced expression of proneural transcription factors has been shown to direct neuronal
conversion of fibroblasts. Because neurons are postmitotic, conversion efficiencies are an …

Background Prostate cancer is characterized by heterogeneity in the clinical course that
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …

Variance stabilization is a step in the preprocessing of microarray data that can greatly
benefit the performance of subsequent statistical modeling and inference. Due to the often …

To build a credible model for given chemical or biological or clinical data, it may be helpful to
first get somewhat better insight into the data itself before modeling and then to present the …

Oligonucleotide microarrays belong to the basic tools of molecular biology and allow for
simultaneous assessment of the expression level of thousands of genes. Analysis of …

Differential expression (DE) is commonly used to explore molecular mechanisms of
biological conditions. While many studies report significant results between their groups of …