[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

[HTML][HTML] Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls

EF Osimo, T Pillinger, IM Rodriguez… - Brain, behavior, and …, 2020 - Elsevier
Importance The magnitude and variability of cytokine alterations in depression are not clear.
Objective To perform an up to date meta-analysis of mean differences of immune markers in …

Child maltreatment and depression: A meta-analysis of studies using the Childhood Trauma Questionnaire

KL Humphreys, J LeMoult, JG Wear, HA Piersiak… - Child abuse & …, 2020 - Elsevier
Background Researchers have documented that child maltreatment is associated with
adverse long-term consequences for mental health, including increased risk for depression …

The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?

CB Nemeroff - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …

Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: A critical review and meta-analysis.

JJ Chiang, PH Lam, E Chen, GE Miller - Psychological Bulletin, 2022 - psycnet.apa.org
Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Efficacy of adjunctive infliximab vs placebo in the treatment of adults with bipolar I/II depression: a randomized clinical trial

RS McIntyre, M Subramaniapillai, Y Lee, Z Pan… - JAMA …, 2019 - jamanetwork.com
Importance To our knowledge, no study has previously evaluated whether individuals with
bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno …

Inflammation and early life stress: An updated review of childhood trauma and inflammatory markers in adulthood

M Brown, C Worrell, CM Pariante - Pharmacology Biochemistry and …, 2021 - Elsevier
Inflammation, as a neurobiological consequence of childhood trauma, has frequently been
reported across research, however, recent investigations suggest this relationship may be …

[HTML][HTML] Depression profilers and immuno-metabolic dysregulation: Longitudinal results from the NESDA study

F Lamers, Y Milaneschi, CH Vinkers… - Brain, Behavior, and …, 2020 - Elsevier
Background Major depressive disorder (MDD) is linked to higher cardio-metabolic
comorbidity that may in part be due to the low-grade inflammation and poorer metabolic …

Gut dysbiosis dysregulates central and systemic homeostasis via suboptimal mitochondrial function: assessment, treatment and classification implications

G Anderson, M Maes - Current Topics in Medicinal Chemistry, 2020 - ingentaconnect.com
The gut and mitochondria have emerged as two important hubs at the cutting edge of
research across a diverse array of medical conditions, including most psychiatric conditions …

Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults

EL Knight, Y Jiang, J Rodriguez-Stanley… - Brain, Behavior, and …, 2021 - Elsevier
Exposure to and perceptions of stress have been associated with altered systemic
inflammation, but the intermediate processes by which stress links to inflammation are not …