Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

To form epithelial organs cells must polarize and generate de novo an apical domain and
lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …

The balance and distribution of epithelial cell types is required to maintain tissue
homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Epithelial tubes are a fundamental tissue across the metazoan phyla and provide an
essential functional component of many of the major organs. Recent work in flies and …