The role of cow's milk consumption in breast cancer initiation and progression

BC Melnik, SM John, P Carrera-Bastos… - Current Nutrition …, 2023 - Springer
Abstract Purpose of Review This review evaluates cow milk's impact on breast
carcinogenesis by linking recent epidemiological evidence and new insights into the …

Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression

JL Chen, B Du - Journal of cancer research and clinical oncology, 2019 - Springer
Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …

Epitranscriptomic code and its alterations in human disease

RV Kadumuri, SC Janga - Trends in Molecular Medicine, 2018 - cell.com
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA
modifications to date. These developments, together with the recent discovery of writers …

The many faces of obesity and its influence on breast cancer risk

T Agurs-Collins, SA Ross, BK Dunn - Frontiers in oncology, 2019 - frontiersin.org
Obesity is associated with increased risk of breast and other cancers. However, the
complexity of the underlying mechanisms, together with the interplay of diet and physical …

FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner

G Zhou, K Yan, J Liu, L Gao, X Jiang, Y Fan - Cell death discovery, 2021 - nature.com
The aberrant expression of fat mass and obesity-associated protein (FTO) has been
confirmed to be associated with a variety of cancers and participates in the regulation of …

Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors

K Li, H Luo, H Luo, X Zhu - Aging (Albany NY), 2020 - pmc.ncbi.nlm.nih.gov
N6-methyladenosine (m6A), internal modification of mRNA, has recently been reported to be
an important regulatory mechanism affecting tumor proliferation. However, its role in …

The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers

J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …

[HTML][HTML] Recent advances of m6A demethylases inhibitors and their biological functions in human diseases

Y You, Y Fu, M Huang, D Shen, B Zhao, H Liu… - International Journal of …, 2022 - mdpi.com
N6-methyladenosine (m6A) is a post-transcriptional RNA modification and one of the most
abundant types of RNA chemical modifications. m6A functions as a molecular switch and is …

Retrospective study of gene signatures and prognostic value of m6A regulatory factor in non-small cell lung cancer using TCGA database and the verification of FTO

H Shi, J Zhao, L Han, M Xu, K Wang, J Shi… - Aging (Albany …, 2020 - pmc.ncbi.nlm.nih.gov
N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA.
However, little is known about its role in non-small cell lung cancer (NSCLC). In this study, a …

Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase activity

X Han, N Wang, J Li, Y Wang, R Wang… - Chemico-Biological …, 2019 - Elsevier
Nafamostat mesilate is a serine protease inhibitor and used for the treatment of pancreatitis
and cancers. The fat mass and obesity-associated protein (FTO) was identified to be a …