Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations
characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually …

Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …

Background Resistance to chemotherapy in gastric cancer (GC) is a ubiquitous challenge
for its treatment. Yi-qi-hua-yu-jie-du decoction (YJD), an empirical formula in Traditional …

In this work, we utilized the molecular hybridization strategy to design and synthesize novel
1, 2, 3-triazole benzothiazole derivatives K1-26. The antiproliferative activities against MGC …

We synthesized new pyrrole and indole derivatives as human carbonic anhydrase (hCA)
inhibitors with the potential to inhibit the Wnt/β-catenin signaling pathway. The presence of …

As a class of microtubule targeting agents, colchicine binding site inhibitors (CBSIs) are
considered as promising drug candidates for cancer therapy. However, due to adverse …

In this work, we utilized the N-benzylaryl derivative 9 as a lead compound and employed the
molecular hybridization strategy by introducing cinnamoyl fragments to successfully design …

Herein, we present a protocol for the regioselective construction of two kinds of
functionalized pyrrole derivatives, ie, pyrimido [1, 2-a] indole derivatives (PIIDOs) 3–4 from …

Alterations in cellular metabolism, such as dysregulation in glycolysis, lipid metabolism, and
glutaminolysis in response to hypoxic and low-nutrient conditions within the tumor …

Ovarian cancer is currently the second most common malignant tumor among gynecological
cancers worldwide, primarily due to challenges in early diagnosis, high recurrence rates …