The hallmarks of COVID-19 disease

D Tang, P Comish, R Kang - PLoS pathogens, 2020 - journals.plos.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that
has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a …

COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies

D Atri, HK Siddiqi, JP Lang, V Nauffal… - Basic to Translational …, 2020 - jacc.org
Summary Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

CA Devaux, JM Rolain, P Colson, D Raoult - International journal of …, 2020 - Elsevier
ABSTRACT Recently, a novel coronavirus (2019-nCoV), officially known as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic …

Effects of chloroquine on viral infections: an old drug against today's diseases

A Savarino, JR Boelaert, A Cassone… - The Lancet infectious …, 2003 - thelancet.com
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial
effects, the drug has interesting biochemical properties that might be applied against some …

Review of emerging pharmacotherapy for the treatment of coronavirus disease 2019

A Barlow, KM Landolf, B Barlow… - … : The Journal of …, 2020 - Wiley Online Library
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
evolved into an emergent global pandemic. Coronavirus disease 2019 (COVID‐19) can …

Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

MAA Al‐Bari - Pharmacology research & perspectives, 2017 - Wiley Online Library
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other
viruses pose a significant threat to human health. Majority of these viruses are responsible …

Current and future use of chloroquine and hydroxychloroquine in infectious, immune, neoplastic, and neurological diseases: a mini-review

D Plantone, T Koudriavtseva - Clinical drug investigation, 2018 - Springer
The process of finding new therapeutic indications for currently used drugs, defined as
'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an …

Hydroxychloroquine: from malaria to autoimmunity

I Ben-Zvi, S Kivity, P Langevitz, Y Shoenfeld - Clinical reviews in allergy & …, 2012 - Springer
Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since
then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine …

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

E Keyaerts, L Vijgen, P Maes, J Neyts… - … and biophysical research …, 2004 - Elsevier
We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of
the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. Chloroquine is a …

The use of antimalarial drugs against viral infection

S D'Alessandro, D Scaccabarozzi, L Signorini… - Microorganisms, 2020 - mdpi.com
In recent decades, drugs used to treat malaria infection have been shown to be beneficial for
many other diseases, including viral infections. In particular, they have received special …