New insights into the implication of epigenetic alterations in the EMT of triple negative breast cancer
Breast cancer is the most common cancer and leading cause of cancer death among
women worldwide, encompassing a wide heterogeneity of subtypes with different clinical …
women worldwide, encompassing a wide heterogeneity of subtypes with different clinical …
Multi-omics model applied to cancer genetics
In this review, we focus on bioinformatic oncology as an integrative discipline that
incorporates knowledge from the mathematical, physical, and computational fields to further …
incorporates knowledge from the mathematical, physical, and computational fields to further …
A genome-wide association study of heat tolerance in Pacific abalone based on genome resequencing
China produces nearly 90% of the world's abalone. The Pacific abalone, Haliotis discus
hannai, is the main cultured species. Because of the southward migration to subtropical …
hannai, is the main cultured species. Because of the southward migration to subtropical …
Studying PAR-dependent chromatin remodeling to tackle PARPi resistance
C Andronikou, S Rottenberg - Trends in molecular medicine, 2021 - cell.com
Histone eviction and chromatin relaxation are important processes for efficient DNA repair.
Poly (ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and …
Poly (ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and …
Integrating pharmacogenomics data-driven computational drug prediction with single-cell RNAseq to demonstrate the efficacy of a NAMPT inhibitor against …
Simple Summary Prostate cancer (PCa) is the second most common cancer and the second
leading cause of cancer deaths in US men. Resistance to standard medical castration and …
leading cause of cancer deaths in US men. Resistance to standard medical castration and …
Epigenetic regulation of breast cancer metastasis
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of
cancer-related mortality among women worldwide. Recurrent metastasis is associated with …
cancer-related mortality among women worldwide. Recurrent metastasis is associated with …
A three layered histone epigenetics in breast cancer metastasis
D Nandy, SM Rajam, D Dutta - Cell & Bioscience, 2020 - Springer
Thanks to the advancement in science and technology and a significant number of cancer
research programs being carried out throughout the world, the prevention, prognosis and …
research programs being carried out throughout the world, the prevention, prognosis and …
CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression
L Zheng, X Liang, S Li, T Li, W Shang, L Ma, X Jia… - …, 2018 - thelancet.com
Background Histones chaperones have been found to play critical roles in tumor
development and progression. However, the role of histone chaperone CHAF1A in gastric …
development and progression. However, the role of histone chaperone CHAF1A in gastric …
[HTML][HTML] Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells
SM Rajam, PC Varghese, MB Shirude, KM Syed… - European Journal of …, 2024 - Elsevier
Our recent studies revealed the role of mouse Aprataxin PNK-like Factor (APLF) in
development. Nevertheless, the comprehensive characterization of mouse APLF remains …
development. Nevertheless, the comprehensive characterization of mouse APLF remains …
Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness
C Richter, S Marquardt, F Li, A Spitschak… - Journal of Experimental …, 2019 - Springer
Background Bladder cancer progression has been associated with dysfunctional repair of
double-strand breaks (DSB), a deleterious type of DNA lesions that fuel genomic instability …
double-strand breaks (DSB), a deleterious type of DNA lesions that fuel genomic instability …