Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice—which to use regarding disease outcomes?
Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2
diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are …
diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are …
Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis …
R Taylor, C Zhang, D George, S Kotecha… - …, 2024 - thelancet.com
Background Mechanistic studies have established a biological role of sterol metabolism in
infection and immunity with clinical data linking deranged cholesterol metabolism during …
infection and immunity with clinical data linking deranged cholesterol metabolism during …
Reverse cholesterol transport and lipid peroxidation biomarkers in major depression and bipolar disorder: A systematic review and meta-analysis
Background Major depression (MDD) and bipolar disorder (BD) are linked to immune
activation, increased oxidative stress, and lower antioxidant defenses. Objectives To …
activation, increased oxidative stress, and lower antioxidant defenses. Objectives To …
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later
Sepsis and trauma were the primary inciting events. With tremendous the advances in care
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …
Lipid and lipoprotein dysregulation in sepsis: Clinical and mechanistic insights into chronic critical illness
In addition to their well-characterized roles in metabolism, lipids and lipoproteins have
pleiotropic effects on the innate immune system. These undergo clinically relevant …
pleiotropic effects on the innate immune system. These undergo clinically relevant …
The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders
Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …
[HTML][HTML] Association between hypocholesterolemia and mortality in critically ill patients with sepsis: a systematic review and meta-analysis
OBJECTIVE: To ascertain the association between cholesterol and triglyceride levels on ICU
admission and mortality in patients with sepsis. DATA SOURCES: Systematic review and …
admission and mortality in patients with sepsis. DATA SOURCES: Systematic review and …
Plasma apolipoprotein concentrations are highly altered in severe intensive care unit COVID-19 patients: preliminary results from the LIPICOR cohort study
F Begue, K Chemello, B Veeren, B Lortat-Jacob… - International Journal of …, 2023 - mdpi.com
SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism.
Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The …
Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The …
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical …
Objective Approximately one-third of sepsis patients experience poor outcomes including
chronic critical illness (CCI, intensive care unit (ICU) stay> 14 days) or early death (in …
chronic critical illness (CCI, intensive care unit (ICU) stay> 14 days) or early death (in …