[HTML][HTML] Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

B Yang, Y Lin, Y Huang, YQ Shen, Q Chen - Redox biology, 2024 - Elsevier
Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

J Pous, B Baginski, P Martin-Malpartida… - Nature …, 2023 - nature.com
Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures determined in the presence of reducing agents. These structures …

TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth

C Molnar, JP Heinen, J Reina, S Llamazares… - EMBO …, 2024 - embopress.org
Expression of the Drosophila cancer-germline (CG), X-linked, head-to-head gene pair TrxT
and dhd is normally germline-specific but becomes upregulated in brain tumours caused by …

The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster

C Petit, E Kojak, S Webster, M Marra, B Sweeney… - Plos one, 2024 - journals.plos.org
Phosducin-like proteins (PhLP) are thioredoxin domain-containing proteins that are highly
conserved across unicellular and multicellular organisms. PhLP family proteins are …

Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain

D Torres-Campana, B Horard, S Denaud… - PLoS …, 2022 - journals.plos.org
The formation of a diploid zygote is a highly complex cellular process that is entirely
controlled by maternal gene products stored in the egg cytoplasm. This highly specialized …

The Drosophila cancer-germline, head-to-head gene pair TrxT and dhd is dispensable for normal brain development but plays a major role in l (3) malignant brain …

C Molnar, JP Heinen, J Reina, S Llamazares… - bioRxiv, 2023 - biorxiv.org
ABSTRACT Drosophila thioredoxins Deadhead (Dhd) and Thioredoxin-T (TrxT) are
encoded by a head-to-head gene pair in the X chromosome. Akin to human cancer-germline …

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

M Macias, J Pous, B Baginski, P Martin-Malpartida… - 2023 - researchsquare.com
Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures, covering free forms and complexes with activators, substrates and …

Epigenetic control of the ovarian transcriptome in Drosophila melanogaster

DT Campana - 2021 - theses.hal.science
Dynamic regulation of the epigenome underlies cellular plasticity and allows cells to
respond to developmental and differentiation programs. Epigenomic effectors can mediate …

[HENVISNING][C] Contrôle épigénétique du transcriptome ovarien chez Drosophila melanogaster

CPU VIEIRA-HEDDI, L DI STEFANO, AM MARTINEZ…