Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The
alarmin family has been expanding in terms of both number and the concept. It has recently …

Mast cells are primary effectors in allergic reactions, and may have important roles in
disease by secreting histamine and various inflammatory and immunomodulatory …

Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation
and histamine release. Recently, members of the Mas-related G-protein-coupled receptor …

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions.
These effector molecules of the innate immune system of many vertebrates are diverse in …

Cationic host defense (antimicrobial) peptides were originally studied for their direct
antimicrobial activities. They have since been found to exhibit multifaceted …

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic …

Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical
and functional associations with sensory afferent neurons. We reveal that epidermal nerve …