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Advances and future perspectives in epithelial drug delivery
Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …
including xenobiotics, pollen and microbiota. The relative permeability of the various …
Gels as vaginal drug delivery systems
The vagina has been used as a mucosal drug delivery route for a long time. Its single
characteristics can be either limitative or advantageous when drug delivery is considered …
characteristics can be either limitative or advantageous when drug delivery is considered …
Approaches in polymeric nanoparticles for vaginal drug delivery: a review of the state of the art
The vagina is a region of administration with a high contact surface to obtain local or
systemic effects. This anatomical area represents special interest for government health …
systemic effects. This anatomical area represents special interest for government health …
[HTML][HTML] Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases
Gynaecological health is a neglected field of research that includes conditions such as
endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is …
endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is …
In vitro and ex vivo models for evaluating vaginal drug delivery systems
Vaginal drug delivery systems are often preferred for treating a variety of diseases and
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …
Development of long-acting bioadhesive vaginal gels of oxybutynin: Formulation, in vitro and in vivo evaluations
Overactive bladder (OAB) and vaginal dryness are common problems after menopause.
Oxybutynin (OXY) is an antimuscarinic agent that has been available for more than 30 years …
Oxybutynin (OXY) is an antimuscarinic agent that has been available for more than 30 years …
Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids
The main objective of this work was to design thermosensitive and mucoadhesive vaginal
hydrogels able to keep their rheological and mucoadhesive properties after dilution with …
hydrogels able to keep their rheological and mucoadhesive properties after dilution with …
Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate
A Abruzzo, F Bigucci, T Cerchiara, B Saladini… - Carbohydrate …, 2013 - Elsevier
Chitosan/alginate complexes were prepared at different polycation/polyanion molar ratios
and freeze-dried vaginal inserts were obtained for chlorhexidine digluconate local delivery …
and freeze-dried vaginal inserts were obtained for chlorhexidine digluconate local delivery …
Studies and methodologies on vaginal drug permeation
The vagina stands as an important alternative to the oral route for those systemic drugs that
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
Women-specific routes of administration for drugs: A critical overview
The woman's body presents a number of unique anatomical features that can constitute
valuable routes for the administration of drugs, either for local or systemic action. These are …
valuable routes for the administration of drugs, either for local or systemic action. These are …