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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
[HTML][HTML] WNT signaling in disease
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …
WNT signaling in cardiac and vascular disease
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …
[HTML][HTML] The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
M Yu, K Qin, J Fan, G Zhao, P Zhao, W Zeng, C Chen… - Genes & …, 2024 - Elsevier
The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …
The regulation of valvular and vascular sclerosis by osteogenic morphogens
Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once
considered only a passive process of dead and dying cells, vascular calcification has now …
considered only a passive process of dead and dying cells, vascular calcification has now …
Immune-instructive polymers control macrophage phenotype and modulate the foreign body response in vivo
Implanted medical devices often elicit adverse foreign body responses whereby
macrophages play a central role. Here, we identify simple polymers that instruct different …
macrophages play a central role. Here, we identify simple polymers that instruct different …
The peripheral blood mononuclear cell microRNA signature of coronary artery disease
BACKGROUND: MicroRNAs are being used in the oncology field to characterize tumors and
predict the survival of cancer patients. Here, we explored the potential of microRNAs as …
predict the survival of cancer patients. Here, we explored the potential of microRNAs as …
Regulatory mechanisms of baicalin in cardiovascular diseases: a review
L **n, J Gao, H Lin, Y Qu, C Shang, Y Wang… - Frontiers in …, 2020 - frontiersin.org
Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality
worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In …
worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In …
The innate immune response to Aspergillus fumigatus at the alveolar surface
Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne
conidia which are inhaled by humans on a daily basis. When the immune system is …
conidia which are inhaled by humans on a daily basis. When the immune system is …