Macrophage polarization and its role in liver disease

C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021‏ - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022‏ - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Nonalcoholic fatty liver disease and insulin resistance: new insights and potential new treatments

H Kitade, G Chen, Y Ni, T Ota - Nutrients, 2017‏ - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders
worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 …

SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet …

L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni… - …, 2017‏ - thelancet.com
Abstract Sodium-glucose cotransporter (SGLT) 2 inhibitors increase urinary glucose
excretion (UGE), leading to blood glucose reductions and weight loss. However, the impacts …

Sources, stability, encapsulation and application of natural pigments in foods

S Jurić, M Jurić, Ż Król-Kilińska… - Food Reviews …, 2022‏ - Taylor & Francis
In recent years, the replacement of synthetic colorants with natural ones has attracted
increasing consumers' and market interest. Natural colorants include different groups of …

[HTML][HTML] Nutritional importance of carotenoids and their effect on liver health: A review

LI Elvira-Torales, J García-Alonso, MJ Periago-Castón - Antioxidants, 2019‏ - mdpi.com
The consumption of carotenoids has beneficial effects on health, reducing the risk of certain
forms of cancer, cardiovascular diseases, and macular degeneration, among others. The …

Metabolic inflammation—a role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?

N Gehrke, JM Schattenberg - Gastroenterology, 2020‏ - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging
evidence points toward metabolic inflammation as a key process in the fatty liver that …

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

Y Ni, M Nagashimada, F Zhuge, L Zhan, N Nagata… - Scientific reports, 2015‏ - nature.com
Hepatic insulin resistance and nonalcoholic steatohepatitis (NASH) could be caused by
excessive hepatic lipid accumulation and peroxidation. Vitamin E has become a standard …

[HTML][HTML] Anti-inflammatory and anticancer effects of microalgal carotenoids

J Ávila-Román, S García-Gil, A Rodríguez-Luna… - Marine Drugs, 2021‏ - mdpi.com
Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

[HTML][HTML] Anti-obesity effect of carotenoids: direct impact on adipose tissue and adipose tissue-driven indirect effects

L Mounien, F Tourniaire, JF Landrier - Nutrients, 2019‏ - mdpi.com
This review summarizes current knowledge on the biological relevance of carotenoids and
some of their metabolites in obesity management. The relationship between carotenoids …