Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

[HTML][HTML] Reprogramming bacteriophage host range: design principles and strategies for engineering receptor binding proteins

M Dunne, NS Prokhorov, MJ Loessner… - Current opinion in …, 2021 - Elsevier
Highlights•Phages use structurally diverse receptor binding proteins (RBPs) to target
different cell wall structures.•RBPs play a critical role in spatial and temporal positioning of …

[HTML][HTML] Oral inhalation for delivery of proteins and peptides to the lungs

E Fröhlich, S Salar-Behzadi - European Journal of Pharmaceutics and …, 2021 - Elsevier
Oral inhalation is the preferred route for delivery of small molecules to the lungs, because
high tissue levels can be achieved shortly after application. Biologics are mainly …

An overview of antibody conjugated polymeric nanoparticles for breast cancer therapy

A Juan, FJ Cimas, I Bravo, A Pandiella, A Ocaña… - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating
cancer. Active targeting NPs can be generated by conjugation with ligands that bind …

Antibody conjugates-recent advances and future innovations

D Leung, JM Wurst, T Liu, RM Martinez… - Antibodies, 2020 - mdpi.com
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past
30 years. Clinical success rates of antibodies have exceeded expectations, resulting in …

Research progress on chemiluminescence immunoassay combined with novel technologies

Q **ao, C Xu - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Chemiluminescence immunoassay (CLIA) has been greatly developed in the past several
decades due to its good sensitivity and specificity. Nowadays, CLIA has been highly …

Antibody-mediated drug delivery

FB Arslan, K Ozturk, S Calis - International Journal of Pharmaceutics, 2021 - Elsevier
Passive and active targeted nanoparticulate delivery systems show promise to compensate
for lacking properties of conventional therapy such as side effects, insufficient efficiency and …

HER2-targeted therapies in gastric cancer

Y Zhu, X Zhu, X Wei, C Tang, W Zhang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Molecular targeted therapy of cancer has always been the focus of clinicians. Among those
therapeutic targets, the human epidermal growth factor receptor-2 (HER-2) signaling …