1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities

S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …

An evolving role of piperazine moieties in drug design and discovery

RV Patel, S Won Park - Mini Reviews in Medicinal Chemistry, 2013 - ingentaconnect.com
This article purposes to provide insights to piperazine based molecular designs that will
facilitate drug discovery program in future. In our pursuit to summarize the reservoir of …

Effect of electron donating functional groups on corrosion inhibition of mild steel in hydrochloric acid: Experimental and quantum chemical study

A Singh, KR Ansari, J Haque, P Dohare, H Lgaz… - Journal of the Taiwan …, 2018 - Elsevier
The corrosion inhibition performance of three triazine derivatives namely 4-((2-(5, 6-diphenyl-
1, 2, 4-triazin-3-yl) hydrazineylidene) methyl)-N, N-dimethylaniline (HT-1), 3-(2-(4 …

Synthesis, crystal structures and spectroscopic properties of triazine-based hydrazone derivatives; a comparative experimental-theoretical study

MN Arshad, A Bibi, T Mahmood, AM Asiri, K Ayub - Molecules, 2015 - mdpi.com
We report here a comparative theoretical and experimental study of four triazine-based
hydrazone derivatives. The hydrazones are synthesized by a three step process from …

Triazine–benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors

P Singla, V Luxami, K Paul - Bioorganic & medicinal chemistry, 2015 - Elsevier
A new series of triazine–benzimidazole hybrids has been synthesized with different
substitution of primary and secondary amines at one of the position of triazine in moderate to …

Privileged S-Triazines: Structure and Pharmacological Applications

DR Shah, RP Modh, KH Chikhalia - Future medicinal chemistry, 2014 - Taylor & Francis
This review summarizes recent reports on s-triazine and its respective analogs from the
medicinal chemistry angle. Due to its high reactivity and binding characteristic towards …

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

RP Modh, E De Clercq, C Pannecouque… - Journal of enzyme …, 2014 - Taylor & Francis
A series of novel hybrid quinazoline–triazine derivatives was designed and synthesized
from cyanuric chloride and anthranilic acid through sequential reactions, which contain …

Syntheses and molecular docking analysis of some new thiazole and thiazine derivatives as three armed molecules with a triazine ring as a core component: a search …

MG Badrey, SM Gomha, AH Abdelmonsef… - Polycyclic Aromatic …, 2024 - Taylor & Francis
A number of new three-armed heterocycles as thiazoles and thiazines linked to triazine
moiety was prepared starting from cyanuaric chloride and thiothemicarbazide which gave …

Potent heteroaromatic hydrazone based 1, 2, 4-triazine motifs: synthesis, anti-oxidant activity, cholinesterase inhibition, quantum chemical and molecular docking …

K Ahmed, M Bashir, R Bano, M Sarfraz… - Journal of Molecular …, 2023 - Elsevier
Triazine based hydrazone scaffolds possessing impressive biological activities are
synthesized using heteroaromatic aldehydes. The target molecules were characterized by …

Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

M Pathak, H Ojha, AK Tiwari, D Sharma, M Saini… - Chemistry Central …, 2017 - Springer
Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of
nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well …