Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the develo** and adult brain during homeostasis and …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme in
polyunsaturated fatty acid (PUFA) metabolism. The role of ACSL4 in the lipopolysaccharide …

Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel
age-related risk factor for cardiovascular disease–related morbidity and mortality. The …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

Abstract Ischemia/reperfusion (I/R) injury is a phenomenon that the reperfusion of ischemic
organs or tissues aggravates their damage, which poses a serious health threat and …