The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Simple Summary Drug therapy is an important treatment for cancer patients; however, drug
resistance severely affects the survival time and quality of life of cancer patients. Oxidative …

Lactate accumulates to a significant amount in glioblastomas (GBMs), the most common
primary malignant brain tumor with an unfavorable prognosis. However, it remains unclear …

Lipids represent the essential components of membranes, serve as fuels for high-energy
processes, and play crucial roles in signaling and cellular function. One of the key hallmarks …

Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard
clinical treatment of GBM includes a maximal surgical resection followed by concomitant …

Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …