Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Background Comparisons of the gut microbiome of lean and obese humans have revealed
that obesity is associated with the gut microbiome plus changes in numerous environmental …

Food intake profoundly affects systemic physiology. A large body of evidence has indicated
a link between food intake and circadian rhythms, and~ 24‐h cycles are deemed essential …

The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm
of genes involved in lipid metabolism is also disturbed. Although the link between …

Circadian clock perturbation frequently occurs in cancer and facilitates tumor progression by
regulating malignant growth and sha** the immune microenvironment. Emerging …

Background and aims Atherosclerosis (AS) is one of the leading causes of cardiovascular
diseases. Studies have revealed critical roles of microRNAs (miRNAs) in the progression of …

Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear
receptor family and functions as a transcriptional activator in response to circadian changes …

Background Age and obesity are dominant risk factors for several common cardiometabolic
disorders, and both are known to impair adipose tissue function. However, the underlying …

Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various
biological processes, including circadian rhythm, cancer, and metabolism. Here, we …