The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

The biology of bone healing is a rapidly develo** science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …