Acid hydrazides, potent reagents for synthesis of oxygen-, nitrogen-, and/or sulfur-containing heterocyclic rings
Heterocycles form by far the largest of the classical divisions of organic chemistry. Moreover,
they are of immense importance not only both biologically and industrially but also to the …
they are of immense importance not only both biologically and industrially but also to the …
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
The features of the chemistry of 4-thiazolidinone and pyrazole/pyrazolines as
pharmacologically attractive scaffolds were described in a number of reviews in which the …
pharmacologically attractive scaffolds were described in a number of reviews in which the …
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
AA Bekhit, T Abdel-Aziem - Bioorganic & medicinal chemistry, 2004 - Elsevier
The synthesis of novel series of structurally related 1H-pyrazolyl derivatives is described. All
the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by …
the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by …
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents
Four series of pyrazolyl benzenesulfonamide derivatives have been synthesized. The first
series was prepared by cyclization of the intermediate N, N-dimethylaminomethylene-4 [3 …
series was prepared by cyclization of the intermediate N, N-dimethylaminomethylene-4 [3 …
Synthesis and antimicrobial activity evaluation of new 1, 2, 4-triazoles and 1, 3, 4-thiadiazoles bearing imidazo [2, 1-b] thiazole moiety
A series of 4-alkyl/aryl-2, 4-dihydro-5-((6-(4-bromophenyl) imidazo [2, 1-b] thiazol-3-yl)
methyl)-3H-1, 2, 4-triazole-3-thiones (3a–i) and 2-alkyl/arylamino-5-((6-(4-bromophenyl) …
methyl)-3H-1, 2, 4-triazole-3-thiones (3a–i) and 2-alkyl/arylamino-5-((6-(4-bromophenyl) …
Synthesis of novel 1, 3, 4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents
Several 1, 3, 4-trisubstituted pyrazole derivatives were synthesized and screened for their
cytotoxic effect in a primary 3 tumor cell line test at 10 4 M drug concentration. Compounds …
cytotoxic effect in a primary 3 tumor cell line test at 10 4 M drug concentration. Compounds …
Design and synthesis of some substituted 1H-pyrazolyl-thiazolo [4, 5-d] pyrimidines as anti-inflammatory–antimicrobial agents
The synthesis of two novel series of structurally related 1H-pyrazolyl derivatives of thiazolo
[4, 5-d] pyrimidines is described. All the newly synthesised compounds were examined for …
[4, 5-d] pyrimidines is described. All the newly synthesised compounds were examined for …
Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as …
In an aim at develo** new antiproliferative agents, new series of benzothiazole/
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …
Synthesis, characterization and biological activity of some new 1, 3, 4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety
B Chandrakantha, P Shetty, V Nambiyar… - European Journal of …, 2010 - Elsevier
In the present study a series of new 1, 3, 4-oxadiazole derivatives containing 2-fluoro-4-
methoxy moiety were synthesized. These newly synthesized compounds were characterized …
methoxy moiety were synthesized. These newly synthesized compounds were characterized …
Tetrazolo [1, 5-a] quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents
AA Bekhit, OA El-Sayed, E Aboulmagd… - European journal of …, 2004 - Elsevier
Three series of tetrazolo [1, 5-a] quinoline derivatives have been synthesized. The first
series was synthesized starting by the condensation of tetrazolo [1, 5-a] quinoline-4 …
series was synthesized starting by the condensation of tetrazolo [1, 5-a] quinoline-4 …