Neurotransmitters: emerging targets in cancer
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
Understanding the role of dopamine in cancer: past, present and future
CE Grant, AL Flis, BM Ryan - Carcinogenesis, 2022 - academic.oup.com
Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …
classically characterized according to its role in the central nervous system as a …
Chronic stress effects on tumor: pathway and mechanism
H Hong, M Ji, D Lai - Frontiers in oncology, 2021 - frontiersin.org
Chronic stress is an emotional experience that occurs when people encounter something
they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases …
they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases …
GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a …
SH Jiang, LL Zhu, M Zhang, RK Li, Q Yang, JY Yan… - Gut, 2019 - gut.bmj.com
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of
cancer-related death worldwide. Neurotransmitter-initiated signalling pathway is profoundly …
cancer-related death worldwide. Neurotransmitter-initiated signalling pathway is profoundly …
The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in …
L Shi, H Chen, K Chen, C Zhong, C Song, Y Huang… - Clinical Cancer …, 2023 - AACR
Purpose: Temozolomide resistance remains a major obstacle in the treatment of
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
Background Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a
specific subpopulation of cells necessary for cancer initiation and metastasis; however, the …
specific subpopulation of cells necessary for cancer initiation and metastasis; however, the …
[HTML][HTML] Role of dopamine receptors in the anticancer activity of ONC201
ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early
activation of the integrated stress response. Its promising safety profile and broad-spectrum …
activation of the integrated stress response. Its promising safety profile and broad-spectrum …
Biological activity of weekly ONC201 in adult recurrent glioblastoma patients
I Arrillaga-Romany, Y Odia, VV Prabhu… - Neuro …, 2020 - academic.oup.com
Background ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the
blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and …
blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and …
Tumor microenvironment crosstalk between tumors and the nervous system in pancreatic cancer: Molecular mechanisms and clinical perspectives
W Xu, J Liu, J Zhang, J Lu, J Guo - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) exhibits the highest incidence of perineural
invasion among all solid tumors. The intricate interplay between tumors and the nervous …
invasion among all solid tumors. The intricate interplay between tumors and the nervous …
Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy
The recent development of high throughput compound screening has allowed drug
repurposing to emerge as an effective avenue for discovering novel treatments for cancer …
repurposing to emerge as an effective avenue for discovering novel treatments for cancer …