The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Background: Open Access Editor's Choice Review Obesity and Cardiometabolic Risk
Factors: From Childhood to Adulthood by Dorota Drozdz 1,*,†, Julio Alvarez-Pitti 2, 3, 4,† …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Although recent studies have highlighted the impact of gut microbes on the progression of
obesity and its comorbidities, it is not fully understood how these microbes promote these …

The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and
progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids …

Metabolic diseases, featured with dysregulated energy homeostasis, have become major
global health challenges. Patients with metabolic diseases have high probability to manifest …