Doxorubicin—an agent with multiple mechanisms of anticancer activity

M Kciuk, A Gielecińska, S Mujwar, D Kołat… - Cells, 2023 - mdpi.com
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming

R Mattioli, A Ilari, B Colotti, L Mosca, F Fazi… - Molecular Aspects of …, 2023 - Elsevier
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Enhanced Immunogenic Cell Death and Antigen Presentation via Engineered Bifidobacterium bifidum to Boost Chemo-immunotherapy

T He, L Wang, S Gou, L Lu, G Liu, K Wang, Y Yang… - ACS …, 2023 - ACS Publications
The immunogenic cell death (ICD) of tumor cells has aroused great interest in the field of
immunotherapy, mainly due to the production of plentiful tumor-associated antigens (TAAs) …

Mitochondria and doxorubicin-induced cardiomyopathy: a complex interplay

L Schirone, L D'Ambrosio, M Forte, R Genovese… - Cells, 2022 - mdpi.com
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …

Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics

M Wallen, F Aqil, W Spencer, RC Gupta - Cancer letters, 2023 - Elsevier
Chemotherapeutics continue to play a central role in the treatment of a wide variety of
cancers. Conventional chemotherapy involving bolus intravenous doses results in severe …

Designing covalent organic framework‐based light‐driven microswimmers toward therapeutic applications

V Sridhar, E Yildiz, A Rodríguez‐Camargo… - Advanced …, 2023 - Wiley Online Library
While micromachines with tailored functionalities enable therapeutic applications in
biological environments, their controlled motion and targeted drug delivery in biological …

Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

A Malek-Khatabi, MS Razavi, A Abdollahi… - Biomaterials …, 2023 - pubs.rsc.org
Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein
and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to …

Micelle-engineered nanoplatforms for precision oncology

W Gao, A Bigham, M Ghomi, A Zarrabi… - Chemical Engineering …, 2024 - Elsevier
The alliance between nanomaterials and cancer therapy has revolutionized the treatment of
tumor patients. After cardiovascular diseases, cancer is the leading cause of death, so …

[HTML][HTML] Bioactive compound encapsulation: Characteristics, applications in food systems, and implications for human health

A Rezagholizade-Shirvan, M Soltani, S Shokri… - Food chemistry: X, 2024 - Elsevier
Nanotechnology plays a pivotal role in food science, particularly in the nanoencapsulation of
bioactive compounds, to enhance their stability, bioavailability, and therapeutic potential …

Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

BF Far, N Rabiee, S Iravani - RSC advances, 2023 - pubs.rsc.org
Metal–organic frameworks (MOFs) and MXenes have demonstrated immense potential for
biomedical applications, offering a plethora of advantages. MXenes, in particular, exhibit …