Recent advanced technologies for the characterization of xenobiotic-degrading microorganisms and microbial communities

S Mishra, Z Lin, S Pang, W Zhang, P Bhatt… - … in Bioengineering and …, 2021 - frontiersin.org
Global environmental contamination with a complex mixture of xenobiotics has become a
major environmental issue worldwide. Many xenobiotic compounds severely impact the …

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

F Sanz-García, T Gil-Gil, P Laborda, P Blanco… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Antibacterial activity and mechanism of luteolin isolated from Lophatherum gracile Brongn. against multidrug-resistant Escherichia coli

Y Ding, G Wen, X Wei, H Zhou, C Li, Z Luo… - Frontiers in …, 2024 - frontiersin.org
Infections caused by multidrug-resistant (MDR) bacteria have become a major challenge for
global healthcare systems. The search for antibacterial compounds from plants has received …

[HTML][HTML] Systems biology: new insight into antibiotic resistance

P Francine - Microorganisms, 2022 - mdpi.com
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important
threat to public health, resulting from the global propagation of multidrug-resistant strains of …

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa

ML Han, Y Zhu, DJ Creek, YW Lin, AD Gutu… - …, 2019 - journals.asm.org
Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa;
however, resistance to polymyxins has been increasingly reported. Therefore …

Metabolic model guided CRISPRi identifies a central role for phosphoglycerate mutase in Chlamydia trachomatis persistence

NB Chowdhury, N Pokorzynski, EA Rucks… - Msystems, 2024 - journals.asm.org
Upon nutrient starvation, Chlamydia trachomatis serovar L2 (CTL) shifts from its normal
growth to a non-replicating form, termed persistence. It is unclear if persistence reflects an …

Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens

M Sertbas, KO Ulgen - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

[HTML][HTML] Antibiotic resistance: time of synthesis in a post-genomic age

T Gil-Gil, LE Ochoa-Sánchez, F Baquero… - Computational and …, 2021 - Elsevier
Antibiotic resistance has been highlighted by international organizations, including World
Health Organization, World Bank and United Nations, as one of the most relevant global …

Preserving the efficacy of antibiotics to tackle antibiotic resistance

P Laborda, T Gil‐Gil, JL Martínez… - Microbial …, 2024 - Wiley Online Library
Different international agencies recognize that antibiotic resistance is one of the most severe
human health problems that humankind is facing. Traditionally, the introduction of new …

Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics

R Kabra, N Chauhan, A Kumar, P Ingale… - Progress in biophysics …, 2019 - Elsevier
Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …