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The role of omics in the application of adverse outcome pathways for chemical risk assessment
EK Brockmeier, G Hodges, TH Hutchinson… - Toxicological …, 2017 - academic.oup.com
In conjunction with the second International Environmental Omics Symposium (iEOS)
conference, held at the University of Liverpool (United Kingdom) in September 2014, a …
conference, held at the University of Liverpool (United Kingdom) in September 2014, a …
Diversity as opportunity: insights from 600 million years of AHR evolution
The aryl hydrocarbon receptor (AHR) was for many years of interest only to pharmacologists
and toxicologists. However, this protein has fundamental roles in biology that are being …
and toxicologists. However, this protein has fundamental roles in biology that are being …
A cross-species quantitative adverse outcome pathway for activation of the aryl hydrocarbon receptor leading to early life stage mortality in birds and fishes
Dioxin-like compounds (DLCs) elicit adverse effects through activation of the aryl
hydrocarbon receptor (AHR). Prior investigations demonstrated that sensitivity to activation …
hydrocarbon receptor (AHR). Prior investigations demonstrated that sensitivity to activation …
High conservation in transcriptomic and proteomic response of white sturgeon to equipotent concentrations of 2, 3, 7, 8-TCDD, PCB 77, and benzo [a] pyrene
Adverse effects associated with exposure to dioxin-like compounds (DLCs) are mediated
primarily through activation of the aryl hydrocarbon receptor (AHR). However, little is known …
primarily through activation of the aryl hydrocarbon receptor (AHR). However, little is known …
Exposure of Persian sturgeon (Acipenser persicus) to cadmium results in biochemical, histological and transcriptional alterations
Sturgeon is one of the endangered families of fish in the Caspian Sea region, where there is
up to 80% of their global caching. Unfortunately, in recent years, increase of pollutants has …
up to 80% of their global caching. Unfortunately, in recent years, increase of pollutants has …
A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka
The novel brominated flame retardants (NBFRs), bis (2-ethylhexyl)-2, 3, 4, 5-
tetrabromophthalate (TBPH) and 2-ethylhexyl-2, 3, 4, 5 tetrabromobenzoate (TBB) are …
tetrabromophthalate (TBPH) and 2-ethylhexyl-2, 3, 4, 5 tetrabromobenzoate (TBB) are …
Measured and predicted affinities of binding and relative potencies to activate the AhR of PAHs and their alkylated analogues
Polycyclic aromatic hydrocarbons (PAHs) and their alkylated forms are important
components of crude oil. Both groups of PAHs have been reported to cause dioxin-like …
components of crude oil. Both groups of PAHs have been reported to cause dioxin-like …
Differences in activation of aryl hydrocarbon receptors of white sturgeon relative to lake sturgeon are predicted by identities of key amino acids in the ligand binding …
Dioxin-like compounds (DLCs) are pollutants of global environmental concern. DLCs elicit
their adverse outcomes through activation of the aryl hydrocarbon receptor (AhR). However …
their adverse outcomes through activation of the aryl hydrocarbon receptor (AhR). However …
Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
L Aranguren-Abadía, R Lille-Langøy… - … science & technology, 2019 - ACS Publications
The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor that mediates
the toxicity of halogenated and polycyclic aromatic hydrocarbons in vertebrates. Atlantic cod …
the toxicity of halogenated and polycyclic aromatic hydrocarbons in vertebrates. Atlantic cod …
Toxicogenomics of gold nanoparticles in a marine fish: Linkage to classical biomarkers
In the present study, the underlying short-term effects of gold nanoparticles (AuNP, spheres,
citrate coated,∼ 40 nm) on the hepatic function of gilthead sea bream (Sparus aurata) was …
citrate coated,∼ 40 nm) on the hepatic function of gilthead sea bream (Sparus aurata) was …