The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Parkinson's disease (PD) is the most common movement disorder and the second most
prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of …

The molecular mechanisms underlying the cellular lost found in the nigrostriatal pathway
during the progression of Parkinson's disease (PD) are not completely understood. Human …

Grapefruit (Citrus paradisi Macf.) is an important cultivar of the Citrus genus which contains a
number of nutrients beneficial to human health. The objective of the present study was to …

6-Hydroxydopamine is a neurotoxin commonly used to lesion dopaminergic pathways and
generate experimental models for Parkinson disease, however, the cellular mechanism of 6 …

Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like
biological activity. Ginseng, the root of Panax ginseng CA Meyer (Araliaceae), is a popular …

The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found
in the 5′ flanking region of many phase II detoxification enzymes. Up-regulation of ARE …

Parkinson's disease (PD) is a neurodegenerative disorder for which available treatments
provide symptom relief but do not stop disease progression. Mitochondria, and in particular …

Mitochondrial alterations have been associated with the cytotoxic effect of 6-
hydroxydopamine (6-OHDA), a widely used neurotoxin to study Parkinson's disease. Herein …

Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF
receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved …