[HTML][HTML] SARS-CoV-2 viral load and shedding kinetics

O Puhach, B Meyer, I Eckerle - Nature Reviews Microbiology, 2023 - nature.com
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two
key parameters for estimating infectiousness. As shedding of infectious virus is required for …

[HTML][HTML] Diagnostics for COVID-19: moving from pandemic response to control

RW Peeling, DL Heymann, YY Teo, PJ Garcia - The Lancet, 2022 - thelancet.com
Diagnostics have proven to be crucial to the COVID-19 pandemic response. There are three
major methods for the detection of SARS-CoV-2 infection and their role has evolved during …

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

SH Hodgson, K Mansatta, G Mallett, V Harris… - The lancet infectious …, 2021 - thelancet.com
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …

[HTML][HTML] Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection

A Natarajan, S Zlitni, EF Brooks, SE Vance, A Dahlen… - Med, 2022 - cell.com
Background COVID-19 manifests with respiratory, systemic, and gastrointestinal (GI)
symptoms. 1, SARS-CoV-2 RNA is detected in respiratory and fecal samples, and recent …

Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening

DB Larremore, B Wilder, E Lester, S Shehata… - Science …, 2021 - science.org
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can
spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the …

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

FA Lempp, LB Soriaga, M Montiel-Ruiz, F Benigni… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—
relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically …

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

JJ Frere, RA Serafini, KD Pryce, M Zazhytska… - Science translational …, 2022 - science.org
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …

Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors

K Guo, S Wustoni, A Koklu, E Díaz-Galicia… - Nature Biomedical …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for
rapid and sensitive protein detection and quantification in simple and robust formats for …

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

L Zhang, A Richards, MI Barrasa… - Proceedings of the …, 2021 - National Acad Sciences
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …