The glymphatic system: a beginner's guide

NA Jessen, ASF Munk, I Lundgaard… - Neurochemical …, 2015‏ - Springer
The glymphatic system is a recently discovered macroscopic waste clearance system that
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …

Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis

BA Corliss, MS Azimi, JM Munson, SM Peirce… - …, 2016‏ - Wiley Online Library
Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

The role of inflammation in lymphedema: a narrative review of pathogenesis and opportunities for therapeutic intervention

C Bowman, SG Rockson - International journal of molecular sciences, 2024‏ - mdpi.com
Lymphedema is a chronic and progressive disease of the lymphatic system characterized by
inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses …

Imaging the perivascular space as a potential biomarker of neurovascular and neurodegenerative diseases

J Ramirez, C Berezuk, AA McNeely, F Gao… - Cellular and molecular …, 2016‏ - Springer
Although the brain lacks conventional lymphatic vessels found in peripheral tissue, evidence
suggests that the space surrounding the vasculature serves a similar role in the clearance of …

New mechanisms of tumor‐associated macrophages on promoting tumor progression: recent research advances and potential targets for tumor immunotherapy

Q Guo, Z **, Y Yuan, R Liu, T Xu, H Wei… - Journal of …, 2016‏ - Wiley Online Library
The majority of basic and clinical studies have shown a protumor function of tumor‐
associated macrophages (TAMs), which represent a large proportion of matrix cells. TAMs …

[HTML][HTML] Sleep disorders and Alzheimer's disease pathophysiology: The role of the Glymphatic System. A sco** review

K Astara, A Tsimpolis, K Kalafatakis… - Mechanisms of ageing …, 2024‏ - Elsevier
Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

The role of the lymphatic system in endometriosis: a comprehensive review of the literature

LF Jerman, AJ Hey-Cunningham - Biology of reproduction, 2015‏ - academic.oup.com
Endometriosis is a benign gynecological disorder characterized by the presence of tissue
resembling the endometrium in locations outside the uterus. The pathogenesis of …

Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer

C Tacconi, F Ungaro, C Correale, V Arena… - Cancer …, 2019‏ - aacrjournals.org
Colorectal cancer is a major cause of cancer-related death in Western countries and is
associated with increased numbers of lymphatic vessels (LV) and tumor-associated …

Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease

JC Serrano, MR Gillrie, R Li, SH Ishamuddin… - Advanced …, 2024‏ - Wiley Online Library
The knowledge of the blood microvasculature and its functional role in health and disease
has grown significantly attributable to decades of research and numerous advances in cell …

Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor‐C

L Alderfer, E Russo, A Archilla, B Coe… - The FASEB …, 2021‏ - Wiley Online Library
Dysfunction of the lymphatic system is associated with a wide range of disease phenotypes.
The restoration of dysfunctional lymphatic vessels has been hypothesized as an innovative …