The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning …

Identification of orthologous or paralogous relationships of coding genes is fundamental to
all aspects of comparative genomics. For accurate identification of orthologs among deeply …

Among chordate taxa, the cephalochordates diverged earlier than urochordates and
vertebrates; thus, they retain unique, primitive developmental features. In particular, the …

The fibroblast growth factor (FGF) signalling pathway plays various roles during vertebrate
embryogenesis, from mesoderm formation to brain patterning. This diversity of functions …

Brachyury, a member of T-box gene family, is widely known for its major role in mesoderm
specification in bilaterians. It is also present in non-bilaterian metazoans, such as …

Cephalochordate amphioxus contain two Brachyury genes (AmphiBra1 and AmphiBra2).
Using probes from the highly conserved coding regions, a summation of their expression …

Fish-like larvae were foundational to the chordate body plan, given the basal placement of
free-living lancelets. That body plan probably made it possible for chordate ancestors to …

A cluster of three Specificity Protein (Sp) genes (Sp1-4, Sp5 and Sp6-9) is thought to be
ancestral in both chordates and the wider Eumetazoa. Sp5 and Sp6-9 gene groups are …

The brachyury gene encodes a T-box transcription factor (TF) that is crucial for the
development of the notochord, a novel trait of chordates. Brachyury expression in axial …

Most metazoans have a single copy of the T‐box transcription factor gene Brachyury. This
gene is expressed in cells of the blastopore of late blastulae and the archenteron …