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Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development
YA El-Maradny, MA Badawy, KI Mohamed… - International Journal of …, 2024 - Elsevier
Background The nucleocapsid protein (N protein) is the most abundant protein in SARS-
CoV-2. Viral RNA and this protein are bound by electrostatic forces, forming cytoplasmic …
CoV-2. Viral RNA and this protein are bound by electrostatic forces, forming cytoplasmic …
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral
immunity. RLR signaling also triggers glycolytic reprogramming through glucose …
immunity. RLR signaling also triggers glycolytic reprogramming through glucose …
[HTML][HTML] Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus …
J Li, M Dong, Q Yao, X Dong, Y Chen, J Wen… - Chinese Herbal …, 2024 - Elsevier
Objective Acute lung injury (ALI) is characterized by inflammation and currently lacks an
efficacious pharmacological intervention. The medicine combination of Lonicerae Japonicae …
efficacious pharmacological intervention. The medicine combination of Lonicerae Japonicae …
[HTML][HTML] UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
P Wang, A Harrison, D Yang, J Cahoon, T Geng… - Research …, 2024 - ncbi.nlm.nih.gov
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral
immunity. RLR signaling also triggers glycolytic reprogramming through glucose …
immunity. RLR signaling also triggers glycolytic reprogramming through glucose …
Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1
Ubiquitination is a major posttranslational covalent modification that regulates numerous
cellular processes including inflammasome signaling. Cells also contain unanchored …
cellular processes including inflammasome signaling. Cells also contain unanchored …
Ldha Accelerates Primary Cisplatin Resistance in Lung Adenocarcinoma by Modulating Ambra1 Ubiquitination Via Moonlighting Functions
F Xu, Q Wang, Y Zhang, Y Zhang, Y Zhai… - Available at SSRN … - papers.ssrn.com
Lung adenocarcinoma (LUAD), the predominant subtype of non-small cell lung cancer
(NSCLC), poses significant therapeutic challenges due to its aggressive nature and limited …
(NSCLC), poses significant therapeutic challenges due to its aggressive nature and limited …