Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their …

K Kornicka, J Houston, K Marycz - Stem cell reviews and reports, 2018 - Springer
Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention.
Their unique features, including self-renewal, multipotency and immunomodulatory …

Wharton's jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance

I Kalaszczynska, K Ferdyn - BioMed research international, 2015 - Wiley Online Library
Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to
collect lifesaving Wharton's jelly derived mesenchymal stem cells (WJ‐MSC). Evidences that …

Stem cell therapy to cure type 1 diabetes: from hype to hope

P Chhabra, KL Brayman - Stem cells translational medicine, 2013 - academic.oup.com
Type 1 diabetes mellitus (T1D) is a chronic, multifactorial autoimmune disease that involves
the progressive destruction of pancreatic β-cells, ultimately resulting in the loss of insulin …

Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells

LT Nguyen, DM Hoang, KT Nguyen… - Stem Cells …, 2021 - academic.oup.com
Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent
promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the …

The effect of chronic inflammation and oxidative and endoplasmic reticulum stress in the course of metabolic syndrome and its therapy

M Alicka, K Marycz - Stem Cells International, 2018 - Wiley Online Library
Metabolic syndrome (MetS) is highly associated with a modern lifestyle. The prevalence of
MetS has reached epidemic proportion and is still rising. The main cause of MetS and finally …

[HTML][HTML] Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics

FC Cassidy, C Shortiss, CG Murphy, SR Kearns… - International Journal of …, 2020 - mdpi.com
Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in
numerous disease settings involving impaired regeneration because of the crucial role they …

Concise review: mesenchymal stem cells for diabetes

J Domínguez-Bendala, G Lanzoni… - Stem cells …, 2012 - academic.oup.com
Mesenchymal stem cells (MSCs) have already made their mark in the young field of
regenerative medicine. Easily derived from many adult tissues, their therapeutic worth has …

Making surrogate β-cells from mesenchymal stromal cells: perspectives and future endeavors

RR Bhonde, P Sheshadri, S Sharma… - The international journal of …, 2014 - Elsevier
Generation of surrogate β-cells is the need of the day to compensate the short supply of
islets for transplantation to diabetic patients requiring daily shots of insulin. Over the years …

Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo

SM Phadnis, MV Joglekar, MP Dalvi, S Muthyala… - …, 2011 - Taylor & Francis
Background aims. The scarcity of human islets for transplantation remains a major limitation
of cell replacement therapy for diabetes. Bone marrow-derived progenitor cells are of …

High glucose-induced reactive oxygen species generation promotes stemness in human adipose-derived stem cells

NC Cheng, TY Hsieh, HS Lai, TH Young - Cytotherapy, 2016 - Elsevier
Background aims Adipose-derived stem cells (ASCs) represent an important source of cell
therapy to treat diabetic complications. However, hyperglycemia may alter several cellular …