Hindered phenols find a wide variety of applications across many different industry sectors.
Butylated hydroxytoluene (BHT) is a most commonly used antioxidant recognized as safe for …

The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …

Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most
aggressive breast cancer subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl …

This study demonstrates that the flavonoid quercetin (Q), a plant-derived compound with low
toxicity in vivo, greatly potentiates the growth-inhibitory activity of Adriamycin (ADR) on MCF …

Summary 30 years ago an anthracycline antibiotic was shown to have antineoplastic activity.
This led to the development of well over 1000 analogues with a vast spectrum of …

Development of multidrug resistance due to overexpression of P-glycoprotein (Pgp), a cell
membrane drug efflux pump, occurs commonly during in vitro selections with adriamycin …

The outcome of cancer metastasis depends on the interaction of metastatic cells with various
host factors. The implantation of human cancer cells into anatomically correct (orthotopic) …

We determined the effects of organ environment on the response of murine CT‐26 colon
carcinoma cells to 2 structurally and pharmacologically distinct chemotherapeutic agents …

We have demonstrated that in vitro resistance of tumor cells to doxorubicin (Dox) can be fully
circumvented by using doxorubicin-loaded nanospheres (Dox-NS), consisting of …

The glutathione S-transferases (GST) are a family of isoenzymes serving a major role in the
biotransformation of many reactive compounds. The isoenzymes from rat, man and mouse …