[HTML][HTML] The basic immunology of asthma

H Hammad, BN Lambrecht - Cell, 2021 - cell.com
In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Understanding asthma phenotypes, endotypes, and mechanisms of disease

ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019 - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Immunologic mechanisms in asthma

T Boonpiyathad, ZC Sözener, P Satitsuksanoa… - Seminars in …, 2019 - Elsevier
Asthma is a chronic airway disease, which affects more than 300 million people. The
pathogenesis of asthma exhibits marked heterogeneity with many phenotypes defining …

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

M Depner, DH Taft, PV Kirjavainen, KM Kalanetra… - Nature medicine, 2020 - nature.com
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

Interleukin-1 and related cytokines in the regulation of inflammation and immunity

A Mantovani, CA Dinarello, M Molgora, C Garlanda - Immunity, 2019 - cell.com
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …