Local drug delivery for enhancing fracture healing in osteoporotic bone

L Kyllönen, M D'Este, M Alini, D Eglin - Acta biomaterialia, 2015 - Elsevier
Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …

The multiple functions of melatonin in regenerative medicine

M Majidinia, RJ Reiter, SK Shakouri, I Mohebbi… - Ageing research …, 2018 - Elsevier
Melatonin research has been experiencing hyper growth in the last two decades; this relates
to its numerous physiological functions including anti-inflammation, oncostasis, circadian …

Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways

KH Park, JW Kang, EM Lee, JS Kim… - Journal of pineal …, 2011 - Wiley Online Library
Although melatonin has a variety of biological actions such as antitumor, antiangiogenic,
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …

Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures

J Zhu, S Yang, K Cai, S Wang, Z Qiu, J Huang… - …, 2020 - pmc.ncbi.nlm.nih.gov
Rationale: Poly (methyl methacrylate)(PMMA) bone cement is one of the most commonly
used biomaterials for augmenting/stabilizing osteoporosis-induced vertebral compression …

Melatonin in the oral cavity: physiological and pathological implications

RJ Reiter, SA Rosales‐Corral, XY Liu… - Journal of …, 2015 - Wiley Online Library
Background and Objectives The purpose of this article was to summarize what is known
about the function of melatonin in the oral cavity. Material and Methods Databases were …

Melatonin increases bone mass around the prostheses of OVX rats by ameliorating mitochondrial oxidative stress via the SIRT3/SOD2 signaling pathway

W Zhou, Y Liu, J Shen, B Yu, J Bai, J Lin… - Oxidative Medicine …, 2019 - Wiley Online Library
Bone mass loss around prostheses is a major cause of implant failure, especially in
postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely …

Melatonin effects on hard tissues: bone and tooth

J Liu, F Huang, HW He - International Journal of Molecular Sciences, 2013 - mdpi.com
Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the
control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an …

Sustained release of melatonin from GelMA liposomes reduced osteoblast apoptosis and improved implant osseointegration in osteoporosis

L **ao, J Lin, R Chen, Y Huang, Y Liu… - Oxidative Medicine …, 2020 - Wiley Online Library
A reduction in bone mass around an implant is the main cause of implant loosening,
especially in postmenopausal osteoporosis patients. In osteoporosis, excessive oxidative …

[HTML][HTML] Melatonin: A review of its potential functions and effects on dental diseases

M Permuy, M López-Peña… - International journal of …, 2017 - mdpi.com
Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its
secretion, controlled by an endogenous circadian cycle, has been proven to exert …

Systemic administration with melatonin in the daytime has a better effect on promoting osseointegration of titanium rods in ovariectomized rats

MS Zhou, ZS Tao - Bone & Joint Research, 2022 - boneandjoint.org.uk
Aims This study examined whether systemic administration of melatonin would have
different effects on osseointegration in ovariectomized (OVX) rats, depending on whether …