Engineering strategies for immunomodulatory cytokine therapies: challenges and clinical progress

IS Pires, PT Hammond, DJ Irvine - Advanced therapeutics, 2021 - Wiley Online Library
Cytokines are immunoregulatory proteins involved in many pathological states with
promising potential as therapeutic agents. A diverse array of cytokines has been studied in …

Cytokine-encapsulated biodegradable microspheres for immune therapy

NK Egilmez - Immunological Investigations, 2020 - Taylor & Francis
Therapeutic macromolecules such as proteins are conventionally administered via bolus
injection, an approach that presents significant limitations. Sustained-release biodegradable …

Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C

PLM Jansen, J De Bruijne - Expert opinion on investigational drugs, 2012 - Taylor & Francis
Introduction: Combination therapy with pegylated interferon alpha (Peg-interferon) and
ribavirin is currently the cornerstone of antiviral therapy for chronic hepatitis C. Monotherapy …

Microencapsulation of alpha interferons in biodegradable microspheres

V Saez, J Ramón, C Peniche, E Hardy - Journal of Interferon & …, 2012 - liebertpub.com
The immunomodulatory, antiproliferative, and antiviral properties of interferons alpha (IFN-α)
have made these cytokines attractive for numerous clinical applications. However, most of …

Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses

S Pollok, T Ginter, K Günzel, J Pieper, A Henke… - Cellular …, 2013 - Elsevier
Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments.
However, clinical success is still hampered due to its limited bioavailability and thus, lack of …

Treatment with Interferon and Ribavirin

W Kemp, SK Roberts - Chronic Hepatitis C Virus: Advances in Treatment …, 2012 - Springer
The natural history of chronic hepatitis C virus (HCV) infection is one of disease progression
with worsening liver fibrosis leading to the development of cirrhosis and related …

Multiplex PCR assay for detection of human somatotropin and interferon alpha2b genes in plant material

IM Gerasymenko, MG Mazur, YV Sheludko… - Cytology and …, 2015 - Springer
Using transgenic plants as factories for production of physiologically active human proteins
arouses special concern because occasional escape of such transgenes into environment …

[PDF][PDF] Emerging therapies in pipeline for chronic hepatitis C

N Kaur, H Negi, A Pandey - International Journal of Basic & Clinical …, 2013 - academia.edu
Hepatitis C infection represents a major global public health problem; as it leads to
significant morbidity, mortality, and financial burden on healthcare system. According to …

[การอ้างอิง][C] 干扰素 α 缓释微球的制备及体外释放研究

孟乐乐, 洪晓芸, 张奇昕, 吴造展, 张丽君, 廖美玲… - 现代生物医学进展, 2012

[การอ้างอิง][C] Clinical application of interferons

BX Wang, R Rahbar, EN Fish - Viruses and Interferon: Current …, 2011 - Horizon Press