The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

In the last 10 years, we have learned much about the pathogenesis, diagnosis, and
management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a …

Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease.
Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive …

Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition
contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation …

Background During the last decade, mesenchymal stem cells (MSCs) have gained much
attention in the field of regenerative medicine due to their capacity to differentiate into …

Idiopathic pulmonary fibrosis (IPF) is a severe form of lung fibrosis with a high mortality rate.
However, the etiology of IPF remains unknown. Here, we report that alterations in lung …

In addition to mesenchymal cells, endothelial cells may contribute to fibrosis through the
process of endothelial-to-mesenchymal transition (EndoMT). We investigated whether …

Endometriosis is a gynecologic disease affecting up to 10% of the women and a major
cause of pain and infertility. It is characterized by the implantation of functional endometrial …

Innate immune responses and rapid recruitment of leukocytes, which regulate inflammation
and subsequent healing, play a key role in acute myocardial infarction (MI). Peptidylarginine …