Cancer immune evasion through loss of MHC class I antigen presentation
K Dhatchinamoorthy, JD Colbert, KL Rock - Frontiers in immunology, 2021 - frontiersin.org
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …
expressed genes and then transport and display this antigenic information on the cell …
Growth/differentiation factor-15 (GDF-15): from biomarker to novel targetable immune checkpoint
Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a
divergent member of the transforming growth factor β superfamily. While physiological …
divergent member of the transforming growth factor β superfamily. While physiological …
Chemokines modulate immune surveillance in tumorigenesis, metastasis, and response to immunotherapy
Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …
immune cells within the tissues. Chemokines are essential for the function of the immune …
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM
The use of inhibitory checkpoint blockade in the management of glioblastoma has been
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …
Tumor-intrinsic PD-L1 signaling in cancer initiation, development and treatment: beyond immune evasion
Although the role of PD-L1 in suppressing the anti-tumor immune response is extensively
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma
Y Bai, C Yang, R Wu, L Huang, S Song, W Li… - Frontiers in …, 2019 - frontiersin.org
YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA
methylation modification. Recent studies have shown that m6A is closely related to multiple …
methylation modification. Recent studies have shown that m6A is closely related to multiple …
Invasive lobular carcinoma of the breast: morphology, biomarkers and'omics
Invasive lobular carcinoma of the breast is the most common 'special'morphological subtype
of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good …
of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good …
Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …
RAS: Striking at the Core of the Oncogenic Circuitry
Cancer is a devastating disease process that touches the lives of millions worldwide.
Despite advances in our understanding of the genomic architecture of cancers and the …
Despite advances in our understanding of the genomic architecture of cancers and the …
Next-generation sequencing to guide cancer therapy
As a result of multiple technological and practical advances, high-throughput sequencing,
known more commonly as “next-generation” sequencing (NGS), can now be incorporated …
known more commonly as “next-generation” sequencing (NGS), can now be incorporated …