The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

The ability to computationally generate novel yet physically foldable protein structures could
lead to new biological discoveries and new treatments targeting yet incurable diseases …

Proteins are the molecular machinery of the human body, and their malfunctioning is often
responsible for diseases, making them crucial targets for drug discovery. The three …

Raman spectroscopy has become an essential tool for chemists, physicists, biologists and
materials scientists. In this article, we present the challenges in unravelling the molecule …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly
synthesized proteins destined for the cell surface or released into the extracellular milieu …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

The pathophysiology of brain and spinal cord injury (SCI) is complex and involves multiple
injury mechanisms that are spatially and temporally specific. It is now appreciated that many …