All cells in the human body are covered by a dense layer of sugars and the proteins and
lipids to which they are attached, collectively termed the “glycocalyx.” For decades, the …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Immunotherapy is a promising approach for treating metastatic breast cancer (MBC), offering
new possibilities for therapy. While checkpoint inhibitors have shown great progress in the …

DNA nanotechnology has established approaches for designing programmable and
precisely controlled nanoscale architectures through specific Watson− Crick base-pairing …

GlycoRNA consists of RNAs modified with secretory N-glycans that are presented on the cell
surface. Although previous work supported a covalent linkage between RNA and glycans …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA, another multifaceted biopolymer, is not thought to be a major target of …

Selective protein degradation platforms have afforded new development opportunities for
therapeutics and tools for biological inquiry. The first lysosome targeting chimeras (LYTACs) …

All neurons are covered in a thick layer of carbohydrates called glycans. Glycans are
modified during neurological processes and are thought to play a role in neuronal …

The endothelial glycocalyx is a dynamic structure on the cell surface comprised of various
components, including glycoproteins, proteoglycans and glycolipids. This structure helps …