The behavioral and pathophysiological role of the dopamine D3 receptor, which was
deduced from anatomical, lesion and drug treatment studies in the ten years following …

Future therapies in Parkinson's disease may substantially build on the existence of intra‐
membrane receptor–receptor interactions in DA receptor containing heteromeric receptor …

The functional specificity of dopamine receptor subtypes remains incompletely understood,
in part due to the absence of highly selective agonists and antagonists. Phenotypic analysis …

A role for inflammation has been hypothesized in the etiology and progression of
Parkinson's disease (PD). In this study, we generated, characterized, and validated the first …

Background Our aim was to determine if pramipexole, a D 3 preferring agonist, effectively
reduced dopamine neuron and fiber loss in the 1-methyl-4-phenyl-1, 2, 3, 6 …

Background Mutants with targeted gene deletion ('knockout') or insertion (transgenic) of D 1,
D 2, D 3, D 4 and D 5 dopamine (DA) receptor subtypes are complemented by an increasing …

Neuropsychiatric disorders represent a substantial social and health care issue. The
National Institutes of Health estimates that greater than 2 million adults suffer from …

Objective To determine whether low concentrations of a dopamine agonist worsen
parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors …

D3 receptors, a key component of the dopamine system, have emerged as a potential target
of therapies to improve motor symptoms across neurodegenerative and neuropsychiatric …

There are contradictory data regarding the role of the dopamine D3 receptor in regulating N-
methyl-d-aspartate (NMDA) receptor antagonist (eg, dizocilpine) induced hyperactivity. The …