Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Point-of-care diagnostics for infectious diseases: From methods to devices

C Wang, M Liu, Z Wang, S Li, Y Deng, N He - Nano today, 2021 - Elsevier
The current widespread of COVID-19 all over the world, which is caused by SARS-CoV-2
virus, has again emphasized the importance of development of point-of-care (POC) …

Klebsiella pneumoniae infection biology: living to counteract host defences

JA Bengoechea, J Sa Pessoa - FEMS microbiology reviews, 2019 - academic.oup.com
Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

[HTML][HTML] Tuberculosis and lung damage: from epidemiology to pathophysiology

S Ravimohan, H Kornfeld… - European respiratory …, 2018 - publications.ersnet.org
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

The multirole of liposomes in therapy and prevention of infectious diseases

R Nisini, N Poerio, S Mariotti, F De Santis… - Frontiers in …, 2018 - frontiersin.org
Liposomes are closed bilayer structures spontaneously formed by hydrated phospholipids
that are widely used as efficient delivery systems for drugs or antigens, due to their capability …

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

L Moreira-Teixeira, PJ Stimpson, E Stavropoulos… - Nature …, 2020 - nature.com
Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …

Urogenital tuberculosis—epidemiology, pathogenesis and clinical features

A Muneer, B Macrae, S Krishnamoorthy… - Nature Reviews …, 2019 - nature.com
Tuberculosis (TB) is the most common cause of death from infectious disease worldwide. A
substantial proportion of patients presenting with extrapulmonary TB have urogenital TB (UG …

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

KM Haas, MJ McGregor, M Bouhaddou… - Nature …, 2023 - nature.com
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …

An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis

RL Paterson, MP La Manna, V Arena De Souza… - Proceedings of the …, 2024 - pnas.org
Peptides presented by HLA-E, a molecule with very limited polymorphism, represent
attractive targets for T cell receptor (TCR)-based immunotherapies to circumvent the …