Design of dry powder inhalers to improve patient outcomes: it's not just about the device

JG Weers - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Introduction Up to 50% of asthma/COPD patients make critical errors in dose preparation
and dose inhalation with current marketed DPIs which negatively impact clinical outcomes …

[HTML][HTML] The effect of lung emptying before the inhalation of aerosol drugs on drug deposition in the respiratory system

Á Farkas, G Tomisa, G Szénási, P Füri, S Kugler… - International Journal of …, 2023 - Elsevier
The amount of drug depositing in the airways depends, among others, on the inhalation
manoeuvre and breathing parameters. The objective of this study was to quantify the effect …

[HTML][HTML] Effect of non-spherical shape of dry powder aerosol drugs on their airway deposition distribution

T Kolonits, S Kugler, A Nagy, P Füri, R Ambrus… - International Journal of …, 2025 - Elsevier
In the majority of aerosol drug deposition modelling efforts, the particles are approximated
by regular spheres. However, microscope images acquired after drug formulation available …

[HTML][HTML] Posaconazole nanocrystals dry powder inhalers for the local treatment of invasive pulmonary aspergillosis

X Li, Q Wang, J Huang, X Yue, X Zhang, X Fan… - International Journal of …, 2025 - Elsevier
Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients,
characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole …

[HTML][HTML] Comparative study of the inhalation parameters of COPD patients through NEXThaler® and Ellipta® dry powder inhalers

Á Farkas, A Horváth, I Réti, N Ilyés, B Havadtői… - Respiratory …, 2024 - Elsevier
The deposition of dry powder aerosol drugs depends on the inhalation parameters of the
patients through the inhaler. These data are not directly measured in clinical practice. Their …

BDP/FF NEXThaler to Improve Asthma Control Status in the Real World: The NEWTON Study

F Braido, E Arnaboldi, S Barile, L Cavalieri… - Journal of Asthma …, 2023 - Taylor & Francis
In this article, we discuss the importance of real-world data in the treatment of patients with
asthma and specifically the role of maintenance and reliever therapy (MART) with …

Real-Time Particle Emission Monitoring for the Non-Invasive Prediction of Lung Deposition via a Dry Powder Inhaler

S Hatazoe, D Hira, T Kondo, S Ueshima, T Okano… - AAPS …, 2024 - Springer
Although inhalation therapy represents a promising drug delivery route for the treatment of
respiratory diseases, the real-time evaluation of lung drug deposition remains an area yet to …

STUDY ON THE INFLUENCE OF TEMPERATURE ON THE SIZE OF PARTICLES DEPOSITED IN IMPACTOR

P Hui, C Hui, X Cong, Y Zhaoqin… - Chinese Journal of …, 2024 - lxxb.cstam.org.cn
The properties of microparticles are almost closely related to the particle size. In order to
study the characteristics of aerosol particles, it is necessary to obtain particle size distribution …

温度对撞击器内颗粒沉积粒径影响的研究

彭慧, 池辉, 徐聪, 尹招琴, 包福兵, 凃程旭 - 力学学报, 2024 - lxxb.cstam.org.cn
微颗粒的性质几乎与颗粒的粒径紧密相关, 为研究气溶胶粒子特性, 需获取颗粒粒径分布信息.
惯性撞击器是一种基于惯性原理实现大气中不同粒径颗粒沉积分离的装置, 在实际使用过程中 …

Development of Novel Formulated Ciprofloxacin Hydrochloride Containing dry Powder Inhalation System

E Benke - 2023 - search.proquest.com
Inhalation therapy dates back a long time [1], but research and product development for
pulmonary drug delivery (PDD) has been focused on the last two to three decades at least …