The formation and wiring of the vertebrate nervous system involves the spatially and
temporally ordered production of diverse neuronal and glial subtypes that are molecularly …

Cdon and Boc, and their Drosophila homologues Ihog and Boi, are evolutionary conserved
transmembrane glycoproteins belonging to a subgroup of the Immunoglobulin superfamily …

A relatively small number of signals are responsible for the variety and pattern of cell types
generated in develo** embryos. In part this is achieved by exploiting differences in the …

Here, we exploit the spatial separation of temporal events of neural differentiation in the
elongating chick body axis to provide the first analysis of transcriptome change in …

Classical descriptions of the hypothalamus divide it into three rostro-caudal domains but
little is known about their embryonic origins. To investigate this, we performed targeted fate …

Holoprosencephaly (HPE) is a frequent congenital malformation of the brain characterized
by impaired forebrain cleavage and midline facial anomalies. Heterozygous mutations in 14 …

The floor plate (FP) is a midline signaling center, known to direct ventral cell fates and axon
guidance in the neural tube. The recent identification of midbrain FP as a source of …

Despite considerable progress, the mechanisms that control neural progenitor differentiation
and behavior, as well as their functional integration into adult neural circuitry, are far from …

Pro-opiomelanocortin (POMC)-expressing neurons in the hypothalamic arcuate nucleus
(ARC) play key roles in feeding and energy homoeostasis, hence their development is of …

Although Hedgehog (HH) signaling plays a critical role in patterning the ventral midbrain, its
role in early midbrain specification is not known. We examined the midbrains of sonic …