Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Thymoquinone and its therapeutic potentials

S Darakhshan, AB Pour, AH Colagar… - Pharmacological …, 2015 - Elsevier
Herbal medicine has attracted great attention in the recent years and is increasingly used as
alternatives to chemical drugs. Several lines of evidence support the positive impact of …

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review

Z Gholamnezhad, S Havakhah… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Nigella sativa (N. sativa) L.(Ranunculaceae), well known
as black cumin, has been used as a herbal medicine that has a rich historical background. It …

Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects

B Amin, H Hosseinzadeh - Planta medica, 2016 - thieme-connect.com
For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the
Ranunculaceae family, have been used as a seasoning spice and food additive in the …

Targeting transcription factor STAT3 for cancer prevention and therapy

EZP Chai, MK Shanmugam, F Arfuso… - Pharmacology & …, 2016 - Elsevier
Abstract Signal Transducers and Activators of Transcription (STATs) comprise an important
class of transcription factors that have been implicated in a wide variety of essential cellular …

Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review

AF Majdalawieh, MW Fayyad - International immunopharmacology, 2015 - Elsevier
Many herbal products are now used as remedies to treat various infectious and non-
infectious conditions. Even though the use of herbs and natural products is much more …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

[HTML][HTML] Thymoquinone: an emerging natural drug with a wide range of medical applications

M Khader, PM Eckl - Iranian journal of basic medical sciences, 2014 - ncbi.nlm.nih.gov
Nigella sativa has attracted healers in ancient civilizations and researchers in recent times.
Traditionally, it has been used in different forms to treat many diseases including asthma …

Potential role of natural compounds as anti-angiogenic agents in cancer

MK Shanmugam, S Warrier, AP Kumar… - Current vascular …, 2017 - ingentaconnect.com
Background: Neovascularization, also known as angiogenesis, is the process of capillary
sprouting from pre-existing blood vessels. This physiological process is a hallmark event in …